Beilstein J. Org. Chem.2022,18, 360–367, doi:10.3762/bjoc.18.40
Abstract Four new phenolicsiderophores were isolated from the actinomycete Nocardia altamirensis along with the known natural product amamistatin B and a putative biosynthetic shunt product. The structures of all compounds were elucidated through 1D and 2D NMR analyses as well as mass spectrometry. The
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Graphical Abstract
Figure 1:
Chemical structures of amamistatins (1–5) and a putative biosynthetic shunt product (6) isolated in...
Beilstein J. Org. Chem.2021,17, 2390–2398, doi:10.3762/bjoc.17.156
Infectious Diseases Research in Africa, University of Cape Town, Rondebosch, 7701, South Africa 10.3762/bjoc.17.156 Abstract Five new phenolicsiderophores 1–5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected
32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1–5 were proposed.
Keywords: Mycobacterium tuberculosis; Phenolicsiderophores
microbial sources led to the isolation of Pseudomonas sp. UIAU-6B from sediments collected from the Oyun river in North Central Nigeria. Herein, we report the isolation and structure elucidation of seven secondary metabolites including five new (1–5), and two known phenolicsiderophores (6 and 7) [28][36
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Graphical Abstract
Figure 1:
Structures of the new phenolic siderophores 1–5, pseudomonine (6), and salicylic acid (7).